Program
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| 8:30 - 3:00 | REGISTRATION OPEN |
| 3:00 - 6:00 | SHORT COURSE: New Molecular and Biological Approaches in PNI |
| Neuroendocrine Measurement in PNI Research | |
| Genomic Approaches in PNI | |
| Impact of Microenvironment on Tumor Growth: Mechanisms and Targets | |
| 6:30 - 8:30 | SENIOR FACULTY/TRAINEE COLLOQUIUM |
| 7:30 - 8:30 | CONTINENTAL BREAKFAST |
| 8:30 - 10:30 | ORAL SESSION 1: Cytokine Effects on the Brain and Behavior: Animal Models |
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Switching transcription factor use preserves cytokine production after NF-kB inhibition in neonatal cerebral hypoxia-ischemia. #104 , Cora Nijboer, Floris Groenendaal, Frank van Bel, Annemieke Kavelaars |
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IL-1 signaling in astrocytes is essential for hippocampal-dependent memory functioning. #150 , Raz Yirmiya, Yair Ben Menahem, Inbal Goshen, Sys Kochavi, Omer Gaist, Tamir Ben Hur |
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Interferon-α and its CNS action: from JAK/STAT signaling to behavioral impact. #88 |
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How does immune activation influence motivated behavior? Autonomic and limbic inputs drive the rostral nucleus accumbens following lipopolysaccharide injection. #94 , Gregory Thacker, Ron Gaykema |
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Alterations in brain and behavioral development of offspring following prenatal flu infection in rhesus monkeys. #100 , Christopher L. Coe, Gabriel Lubach, Martin Styner, John H. Gilmore |
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Minocycline attenuates Lipopolysaccharide (LPS)-induced brain cytokine expression, social withdrawal, and anhedonia. #18 , Yan Huang, Angela Wynne, Justin Himler, Jonathan Godbout |
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Prenatal exposure to endotoxin sensitizes rhesus monkeys to exogenous stress throughout infancy. #48 , Gabriele Lubach, Martin Styner, John Gilmore, Christopher Coe |
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Role of p38 MAP kinase-GRK2 interactions in chronic inflammatory hyperalgesia. #77 , Niels Eijkelkamp, Ilona den Hartog, Cobi J. Heijnen |
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| 10:30 - 11:00 | COFFEE BREAK |
| 11:00 - 12:00 | 2008 NORMAN COUSINS MEMORIAL LECTURE: |
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Cytokines sing the blues: PNI at the translational interface , Emory University |
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| 12:00 - 1:30 | LUNCH BREAK: Roundtable Discussion of NIH Funding Opportunities |
| 1:30 - 3:30 | PRESIDENTIAL SYMPOSIUM: Neural Mediation of the Effects of Stress and Psychological Factors on the Endocrine and Immune Systems |
| Keynote Speaker Interactions between the brain and the periphery in the regulation and dysregulation of emotion, Univ. of Wisconsin, Madison, WI | |
| Social pain: Neurocognitive, neuroendocrine, and immunological correlates, UCLA, CA | |
| Brain regulation of stress reactivity: higher cortical regulation of peripheral activation in response to social threat, Univerrsity of California, Berkeley, CA. | |
| Neuroimaging of autonomic responses to social evaluative threat: Localizing cortical-subcortical-peripheral pathways, Columbia University, NY | |
| 3:30 - 4:00 | COFFEE BREAK |
| 4:00 - 6:00 | ORAL SESSION 2: Effects of Stress, Mood and Cognition on Inflammatory Processes |
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Effects of an acute laboratory stressor on regulatory T cell (Treg) levels in normal human peripheral blood mononuclear cells (PBMC). # 142 , Kevin S. Del Ben |
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Attachment avoidance predicts inflammatory response to marital conflict. #112 , Ronald Glaser, William Malarkey, Timothy Loving, Janice Kiecolt-Glaser |
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University examinations cause hyper-inflammation of mucosal tissues. #89 , Zongjan Fang, Phillip T. Marucha |
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Application of repeated social stress to pregnant gilts during early or late gestation diferentially affects HPA axis and immune system activity of the piglets. #82 , Armelle Prunier, Isabelle Oswald, Francoise Thomas, Anne-Marie Mounier, Elodie Merlot |
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The effects of the physical work environment on circadian variations in heart rate variability. #79 , Julian Thayer, Israel Christie,, Anthony West, Carolyn Sterlin, Darrell Aberneth, Giovanni Cizza, Terry Phillips, Judith Heerwagen, Kevin Kampschroer, John Sollers, Marni Silverman, Esther Sternberg |
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Inflammation as a response to bereavement is associated with increased subgenual anterior cingulate activity. #57 , David Wellisch, Michael Irwin |
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Hostility is related to clusters of T-cell cytokines and chemokines in healthy men. #102 , Paula Mommersteeg, Eric Vermetten, Elbert Geuze, Cobi J. Heijnen |
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Telomere length and pessimistic attitudes in older women. #105 , Jue Lin, Erin Clevenger, Alanie Lazaro, Jean M Tillie, Firdaus S Dhabhar, Owen Wolkowitz, Elizabeth Blackburn, Elissa Epel |
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| 6:00 - 7:30 | COUNCIL MEETING |
| 7:30 | OPENING RECEPTION |
| 7:30 - 8:30 | CONTINENTAL BREAKFAST |
| 8:30 - 10:30 |
SYMPOSIUM I: Impact of Inflammation on the Vulnerable Brain
Chair: Dr. Marina Lynch |
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Systemic inflammation and stroke , Faculty of Life Sciences, Oxford Road, Manchester, UK |
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Functional consequences of the systemic response to brain injury and disease , Department of Pharmacology, University of Oxford, Oxford, UK |
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Neuroinflammation and cognitive and motor impairment in the aged: Evidence for a dysregulated linkage between the immune system and brain , University of Illinois at Urbana Champaign, Urbana, IL. |
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Modulating microglial activation modulates age-related neuroinflammation , Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland |
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| 10:30 - 11:00 | COFFEE BREAK |
| 11:00 - 12:00 |
ROBERT ADER SYMPOSIUM: NEW FRONTIERS IN PNI
Chair: Dr. Jan Moynihan |
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Behavioral regulation of immune response genes , UCLA School of Medicine |
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Perspectives on the crosstalk between the immune and nervous system , University Medical Center |
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The Future Lies in the Past , University of Illinois, Urbana-Champaign |
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Drug Conditioning and the Wisdom of the Body , McMaster University, Hamilton, Ontario, Canada |
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| 12:00 - 1:30 | BBI EDITORIAL BOARD LUNCH |
| 1:30 - 3:30 | ORAL SESSIONS 3 and 4 |
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ORAL SESSION 3 - Cytokines and Behavior: Bidirectional Relationships |
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Acute and chronic IL-1beta administrations differentially modulate learning and memory, acetylcholine efflux and neurotrophin expressions in the hippocampus: possible mechanisms involved in neuroprotection and neurodegeneration. #129 , Pornnarin Teapavarapruk, Ye Zhang |
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Young adult APOE e4 carriers show a stress-induced decline in "hot cognition" and sIL-6r, but not IL-6. #19 , Douglas Walton, Jon Nelson |
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Sleep, sleep deprivation and responses to lipopolysaccharide of interleukin-1b receptor 1 and tumor necrosis factor-a receptor 1 double knockout mice. #152 , M. R. Opp |
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Gender -specific associations between disturbed sleep and biomarkers of inflammation, coagulation and insulin resistance. #93 |
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Chronic stress reduces glucocorticoid and alpha-adrenergic receptor expression, and induces an inflammatory state characterised by increased IL-12 and IFN-gamma production. #45 , Kingston Mills, Thomas Connor |
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Serum Interleukin (IL)-6 and sTNF-R1 are associated with development of multiple symptoms during first 30 days of allogeneic hematopoietic stem cell transplantation. #101 , Sergio Giralt, Qiuling Shi, Loretta Williams, Jemas Rueben, Charles Cleeland |
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Rats infected early in life with bacteria exhibit exaggerated fever, sickness behavior, and lack of endotoxin tolerance in adulthood. #12 , Julie Wieseler, Ruth M. Barrientos, Linda R. Watkins, Steven F. Maier |
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Interferon-γ receptors are required for upregulation of indoleamine 2,3-dioxygenase and depressive-like behavior induced by Bacillus Calmette-Guerin. #144 , Caroline Andre, Marcus A. Lawson, Sandra S. Szegedi, Jacques Lestage, Nathalie Castanon, Keith W. Kelley, Robert Dantzer |
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ORAL SESSION 4 - SNS Mediators, Glucocorticoid Mediators, Viral Outcomes |
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Sympathetic nervous system (SNS) regulation of T-lymphocyte proliferation in aging F344 rats. #135 , Christine Molinaro, Brooke A. Millar, Sam Perez, Cheri Lubahn, Dianne Lorton |
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Social temperament and lymph node innervation. #33 , John Capitanio, Ross Tarara, Steve Cole |
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Disease-induced changes in sympathetic to immune signaling in adjuvant-induced arthritis (AA). #127 , Cheri Lubahn, Tracy Osredkar, Jeff Carter, Terry Der, Denise Bellinger |
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Glucocorticoid eeceptor expression in children shows opposite patterns of associations with anxiety and depression. #87 , Edith Chen |
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Dexamethasone activates Epstein Barr Virus lytic replication through immediate early BZLF1 gene expression. #74 , Eric V. Yang, Min Chen, Jeanette I. Marketon, Marshall V. Williams, Ronald Glaser |
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Optimism is associated with attenuated stressor-induced increases in inflammatory cytokines and negative mood states. #76 , Cicely Walker, Andrew Wawrzyniak, Daisy Whitehead, Andrew Steptoe |
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The association of poor sleep to immunogenicity following an avian flu vaccine in healthy older adults. #153 , John Treanor, Stefan Costescu, Jan Moynihan |
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Effects of social disruption stress on CD4+ T cell activation, trafficking, and survival during influenza infection. #110 , Mark Hanke, Nicole Powell, David Padgett, John Sheridan |
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| 3:30 - 4:00 | COFFEE BREAK |
| 4:00 - 4:30 | POSTER DATA BLITZ (selected presenters A-L see below) |
| 4:30 - 6:30 |
POSTER SESSION 1: First Author names beginning with letters A-L
("First Author" refers to the author listed first on the submitted abstract) |
| 6:30 - 7:30 | PAST TRAINEE - CURRENT TRAINEE ROUNDTABLE |
| 7:30 - | TRAINEE RECEPTION |
| 7:30 - 8:30 | CONTINENTAL BREAKFAST |
| 8:30 - 10:00 | ORAL SESSIONS 5: Psychoneuroimmunology and Cancer |
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Chronic stress promotes tumor growth through a Src-dependent mechanism in a mouse model of ovarian cancer. #34 , Anil K. Sood, Lingegowda S. Mangala, Liz Y. Han, Yvonne G. Lin, Rosemarie Schmandt, Angela M. Sanguino, Gabriel Lopez-Berestein, Susan K. Lutgendorf, Steve W. Cole |
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Stress attenuates the efficacy of IL-12 immunostimulation: An in vivo study of resistance to experimental metastasis. #47 , Shamgar Ben-Eliyahu, Ben Levi, Shaily Shemer |
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Restraint stress increases breast tumor growth and angiogenesis. #21 , Clay Marsh, Tim Eubank, Ryan Roberts, John Sheridan |
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Exercise therapy for ovarian cancer: How does exercise counteract stress-induced tumor growth? #29 , Anil K. Sood, Susan K. Lutgendorf, Lingegowda S. Mangala, Guillermo Armaiz-Pena |
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Marginating pulmonary leukocytes in C57BL/6 mice: Distinct characteristics and enhanced NK cytotoxicity against syngeneic tumor cells. #44 , Shamgar Ben-Eliyahu, Ariella Glasner, Yael Kalderon, Rivka Melamed |
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Norepinephrine upregulates VEGF IL-6, and IL-8 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. #11 , Seung-jae Kim, Elise L. Donovan, Min Chen. Amy Beickelman, Brian J. Hutzen, Jiayuh Lin, Sanford H. Barsky, Ronald Glaser |
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| 10:00 - 10:30 | COFFEE BREAK |
| 10:30 - 12:30 | SYMPOSIA II AND III (concurrent) |
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SYMPOSIUM II: Individual Responses to the Environment: Immune and health correlates
Chair: Dr. Sonia A. Cavigelli |
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Role of acute vs. long-term depressive mood in systemic inflammatory activity and Dr. Greg E. Miller,, University of British Columbia, Vancouver, BC Canada |
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Caregiving, repetitive thought, and serum IL-6 in older adults , Dr. Lindsey J. Schipper and Dr. Richard N. Greenberg, University of Kentucky, Lexington, KY |
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Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality. University of Pittsburgh, PA |
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Female temperament, tumor development and life span: Relation to glucocorticoid and TNFα levels in rats , Dr. Jeanette M. Bennett, Dr. Kerry C. Michael and Dr. Laura Cousino Klein, Pennsylvania State University, University Park, PA |
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SYMPOSIUM III: NeuroAIDS Symposium: HIV and the Brain: Models and Treatment Approaches Co-Chairs: Dr. Keith W. Kelley and Dr. Robert Dantzer |
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Stress, substance abuse and HIV interactions Rockefeller University |
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Role of innate immune responses in the neuropathogenesis induced by SIV in macaques John Hopkins University School of Medicine |
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Neural progenitors and HIV neuropathogenesis University of Pennsylvania School of Medicine |
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Genetic and epigenetic factors in neuroAIDS University of California at San Diego |
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Biomarkers, laboratory, and animal models for the design and development of adjunctive therapies for HIV-1 dementia and other neuroinflammatory disorders University of Nebraska Medical Center |
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| 12:30 - 1:30 | LUNCH (Symposium Discussion) |
| 1:30 - 3:30 |
SYMPOSIA IV: Dynamic innervation of lymphoid tissue: Mechanisms and impact
Chair: Dr. Steve Cole |
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Neuroanatomy of lymphoid innervation: Recent advances and insights Department of Physical Medicine and Rehabilitation, UCI School of Medicine, Orange, CA |
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Psychosocial and viral modulation of lymphoid innervation , UCLA Cousins Center for PNI, CA |
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Injury and sprouting responses of sympathetic nerves in lymphoid organs: Impact on altered immunity in rheumatoid arthritis and potential therapeutic target , Hoover Arthritis Research Center, Sun Health Research Institute |
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Sympathetic innervation across the lifespan: Implications for immune function , Loma Linda University, School of Medicine |
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Dynamic innervation of lymphoid tissue: Themes and implications , UCLA School of Medicine and HopeLab |
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| 3:30 - 4:00 | COFFEE BREAK |
| 4:00 - 4:30 | POSTER DATA BLITZ (selected presenters M-Z see below) |
| 4:30 - 6:00 | POSTER SESSION 2: First Author names beginning with letters M-Z ("First Author" refers to author listed first on the submitted abstract) |
| 6:00 - 7:00 | BUSINESS MEETING |
| 7:00 - | BANQUET |